1072 ALTERED PATHOGENICITY OF ACYCLOVIR (ACV) RESISTANT HSV FROM AN IMMUNODEFICIENT CHILD
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چکیده
منابع مشابه
O and [ { Hg ( ACV ) Cl 2 } x ] . Recognition of acyclovir by Ni – ACV
The monomeric [M(ACV)2(H2O)4]Cl2?2ACV (M = Ni 1 or Co 2), [Zn(ACV)Cl2(H2O)] 3 and the polymeric [Cd(ACV)Cl2]?H2O 4 [ACV = acyclovir = 9-(2-hydroxymethoxymethyl)guanine] complex have been prepared and characterised by X-ray diffraction and IR data; H and C NMR have been used to interpret the structural characteristics of the complexes in solution. Compounds 1 and 2 exist as octahedral complexes ...
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The prevalence and molecular characteristics of isolates from 173 immunocompetent patients with herpetic keratitis (HK) who were infected with acyclovir (ACV)-resistant (ACV(R)) corneal herpes simplex virus (HSV)-1 was determined. Isolates from 11 (6.4%) of the patients were ACV(R), and 9 of these 11 patients were refractory to therapy with ACV; the ACV(R) isolates from 5 and 1 of these 9 patie...
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Herpes simplex virus type 1 (HSV-1) infections in a child with congenital immunodeficiency syndrome were observed over a 10-year period. The child suffered from recurrent and severe HSV-1 mucocutaneous infections. He frequently suffered from acyclovir (ACV)-resistant (ACV(r)) HSV-1 infection in the later phase of his life, especially after the episode of ACV(r) HSV-1 infection. Virological anal...
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BACKGROUND Studies to verify correlations between phenotypes and genotypes of herpes simplex virus (HSV) are an important tool to establish a database of resistance-associated mutations. METHODS In this study, 32 acyclovir (ACV)-resistant clinical HSV-1 and 4 ACV-resistant clinical HSV-2 isolates were examined in parallel by both phenotypic and genotypic resistance testing. Additionally, five...
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Our understanding of the pathogenesis of acyclovir (ACV)-resistant herpes simplex virus (HSV) is limited, especially with regard to reactivation and recurrent disease. To further explore the pathogenesis of ACV-resistant HSV-2 viruses, we used the guinea pig model of genital HSV-2 infection to evaluate several ACV-resistant isolates of both thymidine kinase (Tk)-altered and Tk-deficient phenoty...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1981
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198104001-01098